Protein Details: Potassium voltage-gated channel subfamily E member 1

Protein ID

ICDB_Pro_0349

Protein Name

Potassium voltage-gated channel subfamily E member 1

Gene Name

KCNE1

Organism

Homo sapiens (Human)

Length

129 amino acids

AlphaFoldDB

AF-P15382-F1-model_v4.pdb

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr)

Sequence

MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLGIMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNTHLPETKPSP

PDB Structures

2K21

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Jervell And Lange-Nielsen Syndrome 2 and Long Qt Syndrome 5

Location

Expressed in lung; kidney; testis; ovaries; small intestine; peripheral blood leukocytes. Expressed in the heart (PubMed:19219384). Not detected in pancreas; spleen; prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells.

DOI ID

10.1016/0006-291x(89)91577-5; 10.1016/0378-1119(94)90685-8; 10.1101/gr.2596504; 10.1093/emboj/16.17.5472; 10.1038/40882; 10.1096/fj.01-0520hyp; 10.1007/s00232-009-9154-8; 10.1002/jcp.22265; 10.1074/jbc.m111.235168; 10.1113/jphysiol.2011.211284; 10.1038/srep13399; 10.1021/bi800875q; 10.1006/jmcc.1996.0198; 10.1093/hmg/6.12.2179; 10.1038/ng1197-267; 10.1038/ng1197-338; 10.1161/01.cir.97.2.142; 10.1093/hmg/8.8.1499; 10.1161/01.cir.102.10.1178; 10.1007/s001090100249; 10.1161/01.cir.0000125524.34234.13; 10.1001/jama.294.23.2975; 10.1002/humu.20360; 10.1016/j.hrthm.2009.05.021; 10.1242/jcs.147033

RefSeq

NP_000210.2; NP_001121140.1; NP_001121141.1; NP_001121142.1; NP_001257331.1; NP_001257332.1; NP_001257333.1; NP_001257334.1